Meredith A. Sommars, Ph.D.
Visiting Assistant Professor of Biology
On Faculty since 2022
Postdoctoral Scholar, Chicago, IL June 2019-Present
Ph.D., Life Sciences/Molecular Biology
Driskill Graduate Program, Chicago, IL
M.P.H., Focus in Epidemiology
B.S., Biology, with Distinction
Kriegermeier A., Hyon A., Sommars MA, Hubchak S., LeCuyer B., Liu X., Barish G. and Green RM (2021), Hepatic X-Box Binding Protein 1 and Unfolded Protein Response Is Impaired in Weanling Mice With Resultant Hepatic Injury. Hepatology. https://doi.org/10.1002/hep.32031
Ramachandran K, Senagolage MD, Sommars MA, Futtner CR, Omura Y, Allred AL, et al. (2019) Dynamic enhancers control skeletal muscle identity and reprogramming. PLoS Biol 17(10): e3000467. https://doi.org/10.1371/journal.pbio.3000467
Sommars MA, Ramachandran K, Senagolage MD, Futtner CR, Germain DM, Allred AL, Omura Y, Bederman IR, Barish GD. Dynamic repression by BCL6 controls the genome-wide liver response to fasting and steatosis. eLife 2019; 8. doi: 10.7554/eLife.43922.
Senagolage MD, Sommars MA, Ramachandran K, Futtner CR, Omura Y, Allred AL, Wang J, Yang C, Procissi D, Evans RM, Han X, Bederman IR, Barish GD. Loss of transcriptional repression by BCL6 confers insulin sensitivity in the setting of obesity. Cell Rep 2018; 25(12):3283-3298.e6. doi: 10.1016/j.celrep.2018.11.074.
Alleyne D, Witonsky DB, Mapes B, Nakagome S, Sommars MA, Hong E, Muckala KA, Di Rienzo A, Kupfer SS. Colonic transcriptional response to 1α,25(OH)2 vitamin D3 in African- and European-Americans. J Steroid Biochem Mol Biol. 2017 Apr;168:49-59. doi: 10.1016/j.jsbmb.2017.02.001. Epub 2017 Feb 3. PMID: 28163244; PMCID: PMC5642973.
Mapes B, Sommars (née Chase) MA, Hong E, Ludvik A, Ceryes K, Huang Y, Kupfer SS. Ex vivo culture of primary human colonic tissue for studying transcriptional responses to 1α,25(OH)2 and 25(OH) vitamin D. Physiol Genomics. 2014 Apr 15;46(8):302-8. doi: 10.1152/physiolgenomics.00194.2013. Epub 2014 Feb 18. PMID: 24550213; PMCID: PMC4035659.
Maranville JC, Baxter SS, Witonsky DB, Sommars (née Chase) MA, Di Rienzo A. Genetic mapping with multiple levels of phenotypic information reveals determinants of lymphocyte glucocorticoid sensitivity. Am J Hum Genet. 2013;93(4):735-743. doi:10.1016/j.ajhg.2013.08.005
“Genomic Coordination of Hepatic Lipid Metabolism and Fasting by BCL6.” AbbVie Genomics Research Center seminar series. Invited talk. North Chicago, IL. March 12, 2020.
“Genomic Coordination of Hepatic Lipid Metabolism and Fasting by BCL6.” Membranes, Organelles, and Metabolism (MOM) Series. Invited talk. Chicago, IL. December 2, 2019.
“Genomic Coordination of Hepatic Lipid Metabolism and Fasting by BCL6.” Public dissertation seminar. Invited talk. Chicago, IL. June 13, 2021.
“Protection from steatosis through targeting the transcriptional repressor BCL6.” Cell Symposia: Metabolic Disease Therapies 2017. Poster. San Diego, CA. October 15, 2017.
“BCL6: A novel therapeutic for type 2 diabetes mellitus”. Northwestern University, Lewis Landsberg Research Day. Poster. Chicago, IL. April 2017.
“BCL6 as a Novel Regulator of Hepatic Metabolism and Glucose Homeostasis.” Northwestern University, NUPF Symposium. Poster. Chicago, IL. September 2016.
“BCL6 De-Repression of PPARa as a Therapeutic Strategy for Metabolic Disease.” Northwestern University, Lewis Landsberg Research Day. Poster. Chicago, IL. April 2016.
“De-Repression of PPARa as a Therapeutic Strategy for Metabolic Disease.” Northwestern University, CMBD Training Grant Symposium. Poster. Chicago, IL. March 2016.
“Using tracers in conjunction with metabolic clamps to understand altered glucose homeostasis in a knockout mouse model.” Isotope Tracers in Metabolic Research, NIH/MMPC sponsored course. Invited Talk. Cleveland, OH. November 18, 2015.
“De-Repression of PPARa as a Therapeutic Strategy for Metabolic Disease.” Northwestern University, Genetics and Genomics Cluster Poster Session. Poster. Chicago, IL. August 2015.
“Analysis of Genomic DNase I Hypersensitivity and Gene Regulation.” Duke University Senior Thesis Symposium. Poster. Durham, NC.
“Functional Enhancer Analysis at Random Regions vs. DNase Hypersensitive Sites.” Duke University Summer Research Symposium. Poster. Durham, NC.