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Roger H. Kennett, Ph.D.
Ruth Kraft Strohschein Professor of Biology, Cell Biology
On faculty since 1995

Phone: (630) 752-5317
Fax: (630) 752-5996
Email: roger.h.kennett@wheaton.edu
Education

1969

Ph.D. Princeton University (Biochemical Sciences)

1988

M.S. Ed. Computer Education
University of Pennsylvania Graduate School of Education

1964-69

U.S.P.H.S. Predoctoral Fellow

1964

A. B. Eastern College (Biology)

 
Professional and Personal Interests
Gene expression during development of the zebrafish nervous system

Bioinformatics

Computer education

Courses Taught

  • BIOL 241 & BIOL 242 College Biology I & II
  • BIOL 316 Populations & Evolution
  • BIOL 331 Animal Physiology
  • BIOL 362 Cell & Developmental Biology
  • BIOL 374 Bioinformatics
  • BIOL 385 Neurobiology
  • BIOL 494 Capstone - The Integrated Biologist

Membership in Professional Societies

  • American Association of Immunologists
  • American Association for the Advancement of Science
  • American Scientific Affiliation (Fellow)
  • American Society for Cell Biology
  • American Society for Microbiology
  • Center for Bioethics and Human Dignity
  • Federation of American Societies for Experimental Biology

Research
Students collaborating with Dr. Kennett are studying two aspects of the biology of nerve cells. They have detected antibodies in the sera of multiple sclerosis patients and EAE mice (an MS model system) that react with axolemma preparations (nerve cells with myelin removed). Their goal is to define which cell surface molecules on axons are stimulating the production of these antibodies. This work is being done in cooperation with Dr. George Devries at the VA Hospital in Chicago.

A second project is production of monoclonal antibodies against GABA receptors. These antibodies will be used by Dr. Stephen Roberts at the Uniformed Services Hospital in Bethesda to determine which GABA receptors are expressed on the tumor cells of neuroblastoma patients. This will provide information on how they are likely to respond to different neuroblastoma therapy regimens.

Papers Published and/or Presented

  • Kennett, R. 2003. Technology Evaluation: WX-620, Wilex/Ludwig Institute for Cancer Research. Current Opinions in Molecular Therapeutics 5: 70-75.
  • L. Fan, J. Iyer, S Zhu, K. K. Frick, R. K. Wada, a. E. Eskenazi, P. E. Berg, N. Ikegaki, R. H. Kennett, and C. N. Frantz, 2001. Inhibition of N-myc Expression and Induction of Apoptosis in Human Neuroblastoma Cells. Cancer Research 61: 1073-1079.
  • Roger H. Kennett, 2000. Antibodies to target integrins expressed on tumor vasculature. Current Opinions in Oncologic, Endocrine & Metabolic Investigational Drugs 2000 2(4 376-380.
  • Roger H. Kennett, 1998. "Hybridomas and Monoclonal Antibodies" in Dictionary of Genetics, Salem Press, pp. 330-335.
  • Naohiko. Ikegaki, Xao X. Tang, Brian Kay, and Roger H. Kennett, 1996. Identification of epitope recognized by an anti-c-myc monoclonal antibody that cross-reacts with E. coli sigma factor using phage display libraries. Immunotechnology 2:37-46.
  • H. Ikeda, A. Pastuszko, N. Ikegaki, R.H. Kennett, and D.F. Wilson, 1994. 3, 4-dihydroxyphenylalanine (dopa) metabolism and retinoic acid induced differentiation in human neuroblastoma. Neurochemical Research. 19:1487-94.
  • Linda Engle and Roger H. Kennett, 1994. Cloning, analysis, and chromosomal localization of myoxin, the human homologue to the mouse dilute gene. Genomics 19:407-416.
  • A. Rosolen, L. Whitesell, N. Ikegaki, R.H. Kennett, and L.M. Neckers, 1991. Antisense inhibition of N-Myc reduces cell growth but does not affect C-Myc expression in the neuroepithelioma cell line CHP100. Prog Clin Biol Res. 366:29-36.
  • J. N. Iyer, J., N. , D.N. Krones, N. Ikegaki, R.H. Kennett, and C.N. Frantz, 1991. Regulation of gene expression in human neuroblastoma. Prog Clin Biol Res. 366:55-64.
  • Naohiko Ikegaki, Gretchen Temeles, and Roger H. Kennett, 1991. Modulation of protein expression associated with chemically induced differentiation of neuroblastoma cells. Prog Clin Biol Res. 366: 157-63.

Books:
  • Roger H.:Kennett, Thomas J. McKearn, and Kathleen B. Bechtol, eds., 1980. Monoclonal Antibodies, Hybridomas: A New Dimension in Biological Analyses. Plenum Press., New York.
  • Roger H.:Kennett, Kathleen B. Bechtol, and Thomas J. McKearn, eds. 1984. Monoclonal Antibodies and Functional Cell Lines. Plenum Press, New York.

Translations of Books Published:
  • Roger H.:Kennett, Thomas J. McKearn, and Kathleen B. Bechtol, eds.,1980. Monoclonal Antibodies., A New Dimension in Biological Analyses. Plenum Press. Russian translation, 1983.


Faculty continued: Dr. Fred Van Dyke



 

 

 		  
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