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Overview
Faculty
Courses
Major
Opportunities &
Activities
Careers
& Alumni
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Professional and Personal Interests
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Professionally,
I am interested in protein intercommunication (signal transduction)
and regulation to control physiological activities. Specifically,
I study cGMP-dependent protein kinase (PKG), an enzyme important
in many mammalian (including human) physiological processes
such as blood pressure, platelet aggregation, nerve function,
and gastrointestinal motility.
Personally, I enjoy cycling, spending time outdoors, and reading
historical fiction and biographical books.
| Courses
Taught |
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- BIOL 321 Human Physiology
- BIOL 331 Anatomy and Physiology I
- BIOL 332 Anatomy and Physiology II
- BIOL 334 Pharmacological Physiology
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Membership in Professional Societies
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- American Scientific Affiliation
- Human Anatomy and Physiology Society
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Research |
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Individual: Biochemistry and regulation of PKG.
With Students: Site-directed mutagenesis, protein expression,
and biochemical analyses of PKG in which specific amino acids
have been changed.
| Papers
Published and/or Presented |
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- Busch, Jennifer L., Emmanuel P. Bessay, Sharron H. Francis,
and Jackie D. Corbin, 2002. A conserved serine in PKG-I
contributes to autoinhibition and lower cGMP-binding affinity.
J. Biol. Chem. 277:34048-34054.
- Francis, Sharron H., Celeste Poteet-Smith, Jennifer L.
Busch, Robyn Richie-Jannetta, and Jackie D. Corbin, 2002.
Mechanisms of autoinhibition in cyclic nucleotide-dependent
protein kinases. Front. in Bioscience 7:d580.
- Francis, Sharron H., Der-Ming Chu, Melissa K. Thomas,
Alfreda Beasley, Kennard Grimes, Jennifer L. Busch, Illarion
V. Turko, Tamara L. Haik, and Jackie D. Corbin, 1998. Ligand-induced
conformational changes in cyclic nucleotide phosphodiesterases
and cyclic nucleotide-dependent protein kinases. Methods
14:81-92.
Faculty continued: Dr. Raymond J.
Lewis
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